Pathways To Protection: Options for Managing Inclusion Body Hepatitis (PCPP PSOL 2022)

 

PCPP Poultry School Online (PSOL) 2022

Title of Presentation:

PATHWAYS TO PROTECTION: OPTIONS FOR MANAGING INCLUSION BODY HEPATITIS

________________________________________________________________

Speaker: SHERWIN I. CAMBA, DVM, PhD, Dip. PCPP

________________________________________________________________

Abstract: 

For years, fowl adenoviruses (FAdV) received less attention due to limited clinical importance in poultry production. Based on recent studies, FAdV infections in chickens have undergone substantial changes driven by host, environment, and pathogen factors. It is now considered as a primary pathogen that also causes immunosuppression in poultry. FAdVs mainly infect 3- to 6-week-old broilers and 10- to 20-week-old layers and breeder pullets. This emerging pathogen persistently exists in the environment for a long period of time and is transmitted both horizontally and vertically. The first step of FAdV infection is the attachment of virus to the host cell by binding to the specific receptors on the cell membrane surface before entering via endocytosis, and the genome is transported to the cell nucleus. Inflammatory cytokines, autophagy, apoptosis and maternally derived antibodies may play roles in the pathogenesis of FAdVs.  Although good management practices and adequate biosecurity measures could reduce the incidences of FAdV infection, some strains are resistant to disinfectants and inactivation. Therefore, vaccination against FAdV infection is generally recommended and these vaccines have been proven to be effective in protecting chickens against FAdV infection. Surveillance of the prevalent FAdV serotype is also critical in the success of vaccination.

For more updates please visit https://www.pcpp.org.ph/category/pcpp-updates/